
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
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About
Dive into the microscopic world, radiating with bioluminescent life and unspeakable horrors. Genome Guardian is a deeply-complex shooter that's easy to pick up but hard to master. Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".
Pair DNA nucleotides Adenine (rapidfire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
Bomb + Bomb doubles down on explosive power to make Bazooka!
Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!

49 Turrets with unique strengths and functions
96 Perks to mix and match that drastically change how you play
75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs
64 Mutations alter the challenges you face each run

20-minute Runs that can be continued in Endless Mode
75 Bassy Electronic Tunes that adapt to the current mood & intensity
Cosmetics like spider legs and tank tread
Accessibility Settings for colourblindness, motion sickness, and even arachnophobia!
100 Steam Achievements
Steam Trading Cards
Cloud Save
Plays great on Steam Deck!!!

Stats
All-time low is the lowest price we've recorded for this game since we started tracking it.
Languages: English
Engagement
Hours played at review time, across 41 reviews with recorded playtime.
Reviews
Themes across 40 recent reviews and how positive each mention is. A keyword signal, not full sentiment analysis.
positive critical· bar length = how often the theme comes up
Reviews
One of the strangest Roguelites I've ever played. Not because it's bad or anything but because of the sheer amount of CONTENT. You're likely to spend like, actual days just grinding through all the stuff Genome Guardian has to offer and nowadays there are plenty of Roguelites, or even just games in general that feature a lot of content but for me GG feels different. There's new stuff around every corner, you're constantly unlocking things and trying out new builds and seeing new weapons and mods and it's insane how people hundreds of hours in can STILL see brand new things. 10/10, please buy it, play it, whatever. If you like this one, the sequel is literally the exact same thing with 10x the amount of content. Oh, and the Developer is one of the nicest people ever and despite having a very large community they still manage to treat each of their fans like actual people. They feel like a friend more than a developer and I really appreciate that. You don't get many people nowadays willing to read every review and go through every suggestion.
构筑还挺有意思,但是运气比较重要,而且没中文,太多没用的塔和特性,价格也偏贵。
After nearly 43 hours I'm ready to not recommend this, unfortunately. Multiple times rage quitting, uninstalling, reinstalling, proverbially banging my head against the wall, and the cycle continues. I can beat everything at depth 5 (with different builds nonetheless), but game show mode is GARBAGE. There are just far too many unwinnable scenarios and a lack of rerolling the terms is ridiculous. As for the story I thought all the cryptic messages would culminate to some sort of "you're actually the bad guy fighting off good antibodies" ending, but alas. Maybe I missed something. Though I love the music and sound design, the art style, the creepy factor, the genius combination of weapons (as well as their descriptions), and the receptive nature of the devs. I'll call this a 40/60 toward yes/no for recommending this game. I've already wishlisted the sequel. Even if gameshow mode infuriates me
It's good for wasting time. Besides that, not really worth the price tag.
Absolute banger of a soundtrack The visual style is pretty simple, but I really like these colorful geometric shapes. The UI feels a bit counter-intuitive though There are tons of characters and weapon combinations. Every run can feel different There are multiple game modes, I think I enjoy Shmup the most I wish there was more of permanent "combat" upgrades. I bought all of initial research upgrades pretty quickly, and now there are only cosmetics Overall, the game is definitely worth its price, if you want to get dopamine hits from blowing up neon enemies with your own builds
It shouldn't be this fun, but it is. Building guns to great music just works.
This game was quite the journey to 100%, although if you ask me, I'd definitely highly recommend playing the sequel "Genome Guardian 2" instead over this, as in GG1 it was quite difficult to read the storyline, amongst other minor or/and MAJOR annoyances. In GG2, the story was far more easily readable, it's basically a re-telling of the whole story of GG1 in a sense. Despite that, however, I mostly enjoyed the game despite being aware of the fact that GG2 was out at the time as I was trying to play this a lot on streams. So if you're looking to try out Genome Guardian, gun for Genome Guardian 2 instead, unless you don't mind 100%'ing both of these, of course.. then go ahead. After all, this review isn't here to discourage you from buying GG1, as I still liked it. Definitely a lot of fun moments was had with this, and I only know that in GG2 I'll have way more fun for sure, so can't wait to get back to that in the near-future! Oh, and one last thing, while this game is made in unity, don't get discouraged by it, as you do have various settings in-game you can change, such as the render scale and whatnot if you tend to have a lot of lagspikes & frame drops.. which is honestly something I hope to see in GG2 as well, more game settings to help with performance. But hey, at least on the plus side, you don't have to worry about having to need the most powerful computer either!
I love the complexity of this game and I haven't even scratched the surface. I'm thinking to buy the second version too, in the demo the gameplay feels very refreshing and has lots of QoL features.
Buy this game. Also buy Cell Command. Also buy Genome Guardian 2. Delete all of your other videogames. You won't need them anymore.
this game is just amazing.
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Trends
Modeled estimate over time, reconstructed from Steam's monthly review histogram.
Momentum
Pace estimated from the game's recent review growth (our daily snapshots) at its own sales-per-review ratio — a momentum signal, not booked sales.
Audience
Estimated from the language of this game's reviews — a proxy for where players are, not official Steam demographics.
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